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Antiretroviral cns penetrate regime


From: Durango998457
Added: 7 months ago
Duration: 01:35:38

Central nervous system antiretroviral penetration and

The evidence that there is a disparity between control of HIV in the CNS and the plasma has encouraged a closer look at whether the differences in the relative CNS penetration of antiretroviral drugs provide an opportunity to treat or prevent HIVrelated neurocognitive decline.

CNS Penetration of Antiretroviral Drugs - Medscape

Jul 08, 2014  HIVinfected, antiretroviral therapynaive individuals in the HIVCAUSAL Collaboration who started an antiretroviral regimen were classified according to the CNS Penetration Effectiveness (CPE) score of their initial regimen into low (9) CPE score.

Validation of the CNS Penetration-Effectiveness Rank for

Antiretroviral entry into the CNS is therefore governed largely by multiple inux and efux drug transporters at the bloodbrain barrier and the bloodCSF barrier [1619.

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